Studies with IL-10-/- mice: an overview

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Studies with IL-10-/- mice: an overview.

Our studies have elucidated, in part, the mechanism whereby persistent stimulation by normal enteric antigens leads to the development of chronic enterocolitis in interleukin 10-deficient (IL-10-/-) mice. This disease is mediated by IL-10-/- CD4+ T cells as evidenced by their ability to transfer colitis to immunodeficient RAG-2-/- mice. Furthermore, the CD4+ T cells recovered from the affected ...

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ژورنال

عنوان ژورنال: Journal of Leukocyte Biology

سال: 1997

ISSN: 0741-5400

DOI: 10.1002/jlb.61.4.389